Publications

  • Mark H. Sundman, Bernadette Elise Avila De Vault, Allison Yu-Chin Chen, Lalitha Madhavan, Andrew J. Fuglevand, and Ying-hui Chou. The (hyper)excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging? Neurobiology of Aging.

    https://doi.org/10.1016/j.neurobiolaging.2023.09.007

  • Corenblum MJ, McRobbie-Johnson A, Carruth E, Bernard K, Luo M, Mandarino LJ, Peterson S, Sans-Fuentes MA, Billheimer D, Maley T, Eggers ED, Madhavan L.  Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s disease fibroblasts and midbrain dopamine neurons. Progress in Neurobiology.2023 Oct;229:102501. Epub 2023 Jul 13. PMID: 37451330. PMID: 37451330

    DOI: 10.1016/j.pneurobio.2023.102501

  • MJ Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, LJ Mandarino, S Peterson, D Billheimer, T Maley, ED Eggers, L Madhavan. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s disease fibroblasts and midbrain dopamine neurons.

    bioRxiv 2023.02.10.527867; doi: https://doi.org/10.1101/2023.02.10.527867

  • Anandhan A, Chen W, Nguyen N, Madhavan L, Dodson M1, Zhang DD. α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease. Free Radical Biology and Medicine. 192 (2022) 130–140.

  • Jandova J, Park SL, Corenblum MJ, Madhavan L, Snell JA, Rounds L, Wondrak GT. Mefloquine induces ER stress and apoptosis in BRAFi-resistant A375-BRAFv600E/NRASQ61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model. Molecular Carcinogenesis. 2022 Jun;61(6):603-614. doi: 10.1002/mc.23407. Epub 2022 Apr 13. PMID: 35417045

  • Apostol CR, Bernard K, Tanguturi P, Molnar G, Bartlett MJ, Szabò L, Liu C, Ortiz JB, Saber M, Giordano KR, Green TR, Melvin J, Morrison HW, Madhavan L, Rowe RK, Streicher JM, Heien ML, Falk T, Polt R.  Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP with Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism.  Frontiers in Drug Discovery. 2022 Jan;1:818003. doi: 10.3389/fddsv.2021.818003. Epub 2022 Jan 14. PMID: 35237767.

  • Dodson M, Anandhan A, Zhang DD, and Madhavan L.   An NRF2 perspective on stem cells and ageing.  Frontiers in Aging.  June 15, 2021. https://doi.org/10.3389/fragi.2021.690686

  • Anandhan A, Nguyen N, Syal A, Dreher L, Dodson MB, Zhang DD and Madhavan L. NRF2 loss accentuates Parkinson’s disease pathology and behavioral dysfunction in human alpha-synuclein overexpressing mice. May 2021. Aging and disease, 2021 Jul 1;12(4):964-982. doi: 10.14336/AD.2021.0511. eCollection 2021 Jul. PMID: 34221542

  • Anandhan A, Kirwan KR, Corenblum MJ, and Madhavan L.  Enhanced Nrf2 expression mitigates the decline in neural stem cell function during aging.  Aging Cell. 2021 Jun;20(6):e13385. doi: 10.1111/acel.13385. Epub 2021 Jun 15. PMID: 34128307

  • Schmidlin C, Dodson M, Madhavan L, and Zhang DD. Redox Regulation by NRF2 in Aging and Disease. Free Radical Biology and Medicine. 2019 Jan 14. PMID: 30654017

  • Ray S, Corenblum MJ, Anandhan A, Reed A, Ortiz FO, Zhang DD, Barnes CA, and Madhavan L. A role for Nrf2 expression in defining the aging of hippocampal neural stem cells. Cell Transplantation. 2018 Apr;27(4):589-606. PMID: 29871525

  • Teves JMY, Bhargava V, Kirwan KR, Corenblum MJ, Justiniano R, Wondrak GT, Annadurai A, Flores AJ, Schipper DA, Khalpey Z, Sligh JE, Curiel-Lewandrowski C, Sherman S and Madhavan L. Parkinson’s disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function and autophagy. Front. Neurosci. 2018 Jan 12;11:737. PMID: 2937940

  • Corenblum, M. J., Madhavan, L. Small-scale Propagation of Human iPSCs in Serum-free Conditions for Routine Immunocytochemical Characterization. J. Vis. Exp. (120), e55260, doi:10.3791/55260 (2017).  PMID: 2828757

  • Umashankar A, Corenblum MJ, Ray S, Valdez M, Yoshimaru E, Trouard T, and Madhavan L.  Effects of the iron oxide nanoparticle Molday Ion Rhodamine B on the viability and regenerative function of neural stem cells: Relevance to clinical translation. International Journal of Nanomedicine 2016:11 1731–1748. PMID: 27175074

  • Corenblum MJ, Ray S, Remley QW, Long M, Harder B, Zhang DD, Barnes CA, and Madhavan L. Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period.  Aging Cell. 2016 Apr 20. doi: 10.1111/acel.12482. PMID: 27095375

  • Madhavan L, Daley BF, Davidson BL, Boudreau RL, Cole-Strauss A, Lipton JW, Steece-Collier K, and Collier TJ; Sonic hedgehog controls the phenotypic fate and and therapeutic potential of grafted neural stem cells in a model of nigrostriatal degeneration.  PLOSOne. 2015 Sep 4;10(9):e0137136. PMID: 26340267

  • Corenblum MJ,  Flores AJ, Badowski M, Harris DT, and Madhavan L.  Systemic human CD34+ stem cells populate the brain and activate host-based mechanisms to counteract nigrostriatal neurodegeneration. Regen Med. 2015 Aug;10(5):563-77. PMID: 26237701

  • Madhavan L.  Redox-based regulation of neural stem cell function and Nrf2. Biochemical Society Transactions, Biochem. Soc. Trans. (2015) 43, 627–631

  • Madhavan L. Chapter on Neural Stem Cells for Intrinsic Brain Repair in Aging and Neural Degeneration. Book Title: “Neural Stem Cells in Health and Disease”, World Scientific Publishing Company, Singapore. http://www.worldscientific.com/worldscibooks/10.1142/9309

  • Paumier KL, Sortwell CE, Madhavan L, Terpstra B, Steece-Collier K, Daley BF, and Collier TJ; Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system. Experimental Neurology 2015 Apr;266:11-21. PMID: 25681575

  • Paumier KL, Sortwell CE, Madhavan L, Terpstra B, Daley BF, and Collier TJ; Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism. Neuropsychopharmacology. 2015 Mar;40(4):874-83. PMID: 25267343

  • Paumier K, Siderowf A, Auinger P, Oakes D, Madhavan L, Espay Alberto RF, Collier T; Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease: a retrospective cohort study. Mov Disord. 2012 Jun;27(7):880-7. PMID: 22555881

  • Madhavan L, Daley B, Sortwell C, Collier TJ; Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the Parkinsonian rat. European Journal of Neuroscience; 2012; 2012 Mar;35(6):883-95. PMID: 22417168

  • Gombash SE, Lipton JW, Collier TJ, Madhavan L, Steece-Collier K, Cole-Strauss A, Terpstra BT, Spieles-Engemann AL, Daley BF, Wohlgenant SL, Thompson VB, Manfredsson FP, Mandel RJ, Sortwell CE; Striatal overexpression of pleiotrophin provides functional and morphological neuroprotection in the 6-hydroxydopamine model of Parkinson's Disease; Molecular Therapy; 2012 Mar;20(3):544-54. PMID: 22008908

  • Kordower J, Hemraj D, Kordower A, Terpstra B, Madhavan L, Paumier K, Sortwell C, Steece-Collier K, Collier T. Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat; Neurobiol Dis; 2011 Sep; 43(3):552-7. PMID: 21600984

  • Spieles-Engemann AL, Behbehani MM, Collier TJ, Wohlgenant SL, Madhavan L, Paumier K, Steece-Collier K, Gombash S, Mandybur GT, Lipton X, Sortwell CE; Deep brain stimulation of the rat subthalamic nucleus is neuroprotective following large scale nigral dopamine neuronal degeneration; Neurobiol Dis; 2010 Jul; 39(1):105-15. PMID: 20307668

  • Madhavan L, Collier TJ; A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity; Neuropharmacology; 2010 May; 58 (6):835-44. PMID:19853620

  • Madhavan L, Paumier KL, Daley BF, Collier TJ; Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease; J Comp Neurol; 2009 July 1; 515 (1): 102-15. PMID: 19399899

  • Madhavan L, Ourednik V, Ourednik J; Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor modulated antioxidant expression; Stem Cells; 2008; 26: 254-65. PMID: 17962704

  • Madhavan L, Ourednik V, Ourednik J; Increased "vigilance" of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress; Stem Cells; 2006; 24(9):2110-9. PMID: 16728559

  • Madhavan L, Ourednik V, Ourednik J; Grafted neural stem cells shield the host environment from oxidative stress; Annals New York Academy of Sciences; 2005; 1049: 185-8. PMID: 15965117

  • Madhavan L, William JF, Vellareddy A, Kanthasamy AG; 5-Hydroxytryptamine 1A receptor activation protects against N-Methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures; The Journal of Pharmacology and Experimental Therapeutics (JPET); 2003; 304(3): 913-923. PMID: 12604665